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Mandalay Bay Resort & Casino Map Mandalay Bay Resort & Casino Location Map Address: 3950 Las Vegas Blvd. South, Las Vegas, Nevada, 89109 Location: On the Strip next to Luxor Direction: From I-15: Exit either Russell Road or Tropicana East. Exit Russell Rd. East. At Las Vegas Blvd. turn left (North). go 1/2 block and the entrance will be on the left. Follow the signs for Valet and Self Park. Exit Tropicana East. At Las Vegas Blvd. turn right (South). Go 1/2 block and the entrance will be on the right. Follow the signs for Valet and Self Park. hotel Mandalay Bay Resort & Casino Mandalay Bay Resort & Casino Opened on March 2, 1999, five-star luxury hotel. Main tower: 44 floors, 3700 Rooms & Suites. Casino: 135,000 sf., 1 Buffet, 14 Restaurants, Pool, Spa, Fitness Center, Sand-and-surf beach, Wedding chapel, Gift shops, Meeting and convention space.